The distribution of D1-receptors varies from that of D2-receptors in the human brain which may be one reason for the importance of blocking both D1- and D2-receptors for a full antipsychotic response. Stay just steps from picturesque Lake Blue Ridge a hotspot in the Appalachian Mountains of North Georgia for visitors and locals. The unique clinical profile of clozapine may be related to its potency on both D1- and D2-receptors. The occupation of D1-receptors was higher (40%, 42%) than that of classical compounds (0-36%). Thus, clozapine in conventional doses occupied D2-receptors to a smaller extent (40%, 40%, 65%) than classical neuroleptics. The atypical neuroleptic compound clozapine demonstrated a different binding profile than the classical neuroleptics. The D1-receptor occupancy seemed to be dependent on the type of the antipsychotic compound studied. The degree of binding to D1-receptors using the 11C-labelled D1-antagonist from Schering (SCH 23390) as the ligand was also determined. The results substantiate the opinion that the antipsychotic effects is mediated by a blockade of D2-dopamine receptors. Using the selective D2 receptor antagonist raclopride labelled with positron emitting isotope 11C, it has been shown that chemically distinct classical neuroleptics in conventional doses occupy a high degree (65-89%) of the D2-receptors in the human brain. Positron emission tomography (PET) has made it possible to investigate interactions of psychotropic drugs with central receptors in the living human brain. ![]() No such relationships have been demonstrated for any other central receptor population. ![]() A relationship in vitro between the potency for the antipsychotic effect and the blockade of D2-dopamine receptors has been shown. ![]() It has been unequivocally shown that antipsychotic compounds reduce dopaminergic transmission. North Georgia vacation rentals for every getaway Lifes a Hoot - Suches, GA Unwined Lodge - Dahlonega, GA Country Cottage - Sautee Nacoochee, GA Red Roof.
0 Comments
Leave a Reply. |